<h3><br /></h3><h3><br /></h3><h3> </h3><h3><br /></h3><h3>新版普天登的成分包括四种食品级的原料:绿茶提取物,姜黄提取物,Oligonol荔枝多酚,和黑胡椒提取物。老版普天登的几种成分可以协同激活36倍的Nrf-2,而新版普天登的几种成分可以协同激活90倍的Nrf-2。其中新配方中的亮点就是oligonol。</h3><h3><br /></h3><h3>Oligonol 中文名称为"荔枝多酚",来自于"Oligomer Polyphenol"(多元酚低聚物)的缩写,它是一种从荔枝中提取出来的,能被人体良好吸收的,具有一定功能性的小分子物质。它是世界上由人类工业化生产出的首个小分子多元酚,并被众多严谨的科学实验证实,能被人体有效地吸收,并能发挥良好的抗氧化能力及抗衰老的性能。与一般的大分子多酚类物质相比,更容易被人体吸收。</h3><h3>Oligonol的安全性在早期的众多科学实验中已被证实。多个不同种类的临床实验,毒性试验,动物实验( 90-day Repeated Oral Administration Toxicity Test, Reverse Mutation Test (Ames examination) and Micronucleus Test conducted in rats and Single Oral Administration Toxicity Test conducted in rats)都科学地论证了这种小分子多酚类物质对于人体的安全性。并且,2007年它就通过了美国FDA认证,被授予了NDI 称号 (New Dietary Ingredient全新的膳食组成) 。同时在2009年,它获得了GRAS (Generally Recognized as Safe),一种被认为是很安全的膳食补充剂。</h3><h3>Oligonol作为泰版普天登的新配方之一,其原料来自于日本Amino Up Chemical Co. Ltd。这是一家有着40年历史的高科技生物公司,其中的荔枝多酚是具有国家专利号的多酚类化合物。提炼技术及其生物技术都是世界领先的,具有其他厂家无法比拟和超越的技术。作为一种原料,它被广泛用于胶囊,食物,饮料及化妆品中。</h3><h3><br /></h3><h3>Oligonol主要有以下四大功效</h3><h3><br /></h3><h3>1.心血管疾病的预防及改善:</h3><h3>有一部分人群正遭受着四肢末梢血液循环不良的困扰。吸烟,喝酒,压力,荷尔蒙激素的紊乱,高血压,血栓形成,动脉粥样硬化等因素都会对正常人的血液循环状态有影响。血管内皮细胞的功能之一就是维持微循环的通畅性。然而,由于高血糖带来的氧化应激反应的增加可能会诱导内皮细胞功能的紊乱,从而导致NO(一氧化氮)生成的减少,从而导致人的身体容易受到感染或动脉粥样硬化的侵害。</h3><h3>以下热成像仪的图片记录了一个43岁健康男性接受一次600mg oligonol后明显增加了体表温度,显示血流量增多,外周血管扩张。这个结果说明了对于各种各样的血管收缩性症状比如手脚发凉,肩周炎和糖尿病血管病变,Oligonol可能起到了血管扩张剂的作用。</h3><h3>那如果是低剂量的Oligonol呢?它对于改善血液循环有什么帮助吗?同样通过热成像仪来记录手臂和手掌的实验结果。实验中选取了2位34岁和41岁的健康男性,没有服用过任何膳食补充剂。每位给予50mg的胶囊,早上和晚上各服一粒。实验结果发现服用后30分钟至120分钟,体表的温度明显上升。</h3> <h3>因此,研究证实Oligonol具有强大的抗氧化能力,能消除自由基,防止老化,能有效控制血液中氧化物的浓度,并能保护血管内皮细胞,从而预防及改善心血管疾病。</h3><h3><br /></h3><h3>2.在美容方面的成效:</h3><h3>给予17个26至60岁的女性100mg的oligonol胶囊,一天两次。12周后结果显示oligonol在改善皮肤的状况上有明显的成果。29%以上的人色斑明显变淡,47%以上的皱纹明显减少,尤其在大于40岁以上的妇女中,这种改善尤为明显。 </h3> <h3>其次,在紫外线防护效果上,oligonol同样起到了正面的效果。如果人长期暴露在紫外线下,会产生活性氧(ROS),而活性氧会诱导络氨酸酶的激活,而络氨酸酶会触发黑色素的形成,从而导致皮肤色素沉着。雀斑就是黑色素沉着累计的结果。活性氧也能引起皮肤真皮层胶原蛋白及弹性蛋白的损伤,进一步形成皱纹。</h3><h3>而关于oligonol在皮肤上的研究成果已经发表了数篇论文。</h3><h3><br /></h3><h3>3.Oligonol对运动疲劳的改善作用:</h3><h3>动物实验以及人体实验都证实了服用oligonol的组在运动中疲劳的程度明显小于对照组。而且,也证实了oligonol能帮助消除由于被动运动而产生的过度的氧化应激反应。另一方面,服用oligonol的组在运动后的疲劳恢复上也明显大于对照组。</h3> <h3>此外,Oligonol经世界反兴奋剂机构(the World Anti-Doping Agency (WADA)) 鉴定及评估,未检测出任何含违禁的成分,所以适用于运动员长期口服增加耐力。</h3><h3><br /></h3><h3>4.控制内脏脂肪过多症:</h3><h3>内脏脂肪的增多是不是比皮下脂肪更多地对人体的健康造成伤害?答案是显而易见的。目前已知,由于内脏脂肪的增多而产生的一些蛋白质被统称为不健康的因子。在我们人体中,各种各样的蛋白质担负着不同的使命,并保持身体的健康。但是,当内脏脂肪过多时,某些被称之为"TNF-α,PAI-1, and MCP-1"的蛋白质会引起血管堵塞以及高血糖等一系列临床表现。</h3> <h3>实验证明oligonol作为一种可以调节脂肪因子的成分,可以有效地预防及改善代谢综合征和相关的心脏病。服用oligonol组和对照组相比,明显地减少了皮下脂肪,内脏脂肪以及腹围(腹部CT比较)。</h3> <h3>附</h3><h3>关于oligonol的研究成果在pubmed上已经发表的论文:</h3><h3><br /></h3><h3>附:关于oligonol的研究成果在pubmed上已经发表的论文</h3><h3>2016</h3><h3>76. "Investigation og the Amelioration Effects of Oligonol® on Tinnitus in Randomized Double-blinded Placebo-controlled Trial"</h3><h3>Jun Nishihira (Hokkaido Information University, Japan), Japan Pharmacology & Therapeutics, 44(9): 1329-1336, 2016</h3><h3>75. "Anti-obesity effects of Oligonol in healthy subjects: a double blind, randomized placebo-controlled trial"</h3><h3>Masaki Taga (Wayo Women's University, Japan), Clinical Parmacology and Therapy, 26(3), 85-96, 2016</h3><h3>74. "Global Liver Gene Expression Analysis on a Murine Metabolic Syndrome Model Treated by Low-molecular-weight Lychee Fruit Polyphenol (Oligonol®)"</h3><h3>Koji Wakame (Hokkaido Pharmaceutical University School of Pharamacy, Japan), Anticancer Research, 36(7): 3705-3713, 2016</h3><h3>73. "Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, protects the pancreas from apoptosis and proliferation via oxidative stress in streptozotocin-induced diabetic rats"</h3><h3>Chan Hum Park (National Institute of Horticultural, Korea), Food & Function, 7(7): 3056-3063, 2016</h3><h3>72. "Flavanol-rich lychee fruit extract alleviates diet-induced insulin resistance via suppressing mTOR/SREBP-1 mediated lipogenesis in liver and restoring insulin signaling in skeletal muscle"</h3><h3>Sue-Joan Chang (National Cheng Kung University, Taiwan), Molecular Nutrition & Food Research, 60(10): 2288-2296, 2016</h3><h3>71. "Oligonol, a lychee fruit-derived low-molecular form of polyphenol mixture, suppresses inflammatory cytokine production from human monocytes"</h3><h3>Insoo Kang (Yale University School of Medicine, USA), Human Immunology, 77(6): 512-525, 2016</h3><h3>70. "Low-molecular-weight polyphenols protect kidney damage through suppressing NF-κB and modulating mitochondrial biogenesis in diabetic db/db mice"</h3><h3>Sue-Joan Chang (National Cheng Kung University, Taiwan), Food & Function, 7(4): 1941-1949, 2016</h3><h3>69. "Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway"</h3><h3>Takako Yokozawa (Toyama University, Japan), Nutrition Research and Practice, 10(1): 3-10, 2016</h3><h3>68. "Oligonol Ameliorates CCl4-Induced Liver Injury in Rats via the NK-Kappa B and MAPK Signaling Pathways"</h3><h3>Jeonghyeon Bak (Pusan National University, Korea), Oxidative Medicine and Cellular Longevity, Article ID 3935841, 2016</h3><h3>67. "Inhibitory evaluation of oligonol on α-glucosidase, protein tyrosine phosphatase 1B, cholinesterase, and β-secretase 1 related to diabetes and Alzheimer's disease"</h3><h3>Takako Yokozawa (Toyama University, Japan), Archives of Pharmacal Research, 39(3), 409-420, 2016</h3><h3>2015</h3><h3>66. "Inhibitory effects of several saturated fatty acids and their related fatty alcohols on the growth of Candida albicans"</h3><h3>Kazumi Hayama (Teikyo University Institute of Medical Mycology, Japan), Drug Discoveries & Therapeutics, 9(6): 386-390, 2015</h3><h3>65. "Development a new aroma candy for maintenance of the oral health"</h3><h3>Kazumi Hayama (Teikyo University Institute of Medical Mycology, Japan), Medical Mycology Research, 6(1): 3-9, 2015</h3><h3>64. "Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model"</h3><h3>Jae-Yeo Park (Yonsei University College of Nursing, Korea), BMC Complementary and Alternative Medicine, 15: 185, 2015</h3><h3>63. "Therapeutic Effects of Oligonol, Acupuncture, and Quantum Light Therapy in Chronic Nonbacterial Prostatitis"</h3><h3>Hakan Akdere (Trakya University, Turkey), Evidence-Based Complementary and Alternative Medicine, doi: org/10.1155/2015/687196, 2015</h3><h3>62. "Protective role of oligonol from oxidative stress-induced inflammation in C6 glial cell"</h3><h3>Eun Ju Cho (Pusan National University, Korea), Nutrition Research and Practice, 9(2):123-128, 2015</h3><h3>61. "Analgesic Effects of Oligonol, Acupuncture and Quantum Light Therapy on Chronic Nonbacterial Prostatitis"</h3><h3>Mehmet Burgazli (Wuppertal Research and Medical center, Germany), Iranian Red Crescent Medical Journal, 17(4): e26006, 2015</h3><h3>60. "The Effects of an Aroma Candy on Oral Candida albicans Colony-forming Units (CFU) and Oral Hygiene States in Healthy Elderly Carrying Candida albicans"</h3><h3>Motohumi Suzuki (Institute of Medical Mycology, Teikyo University, Japan), Medical Mycology Journal, 56: J31-J40, 2015</h3><h3>59. "Anti-Candida Activity of Aroma Candy and Its Protective Activity Against Murine Oral Candidasis"</h3><h3>Kazumi Hayama (Institute of Medical Mycology, Teikyo University, Japan), Medical Mycology Journal, 56: J23-J29, 2015</h3><h3>58. "Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity mediated renal disorder in type 2 diabetic db/db mice"</h3><h3>Chan Hum Park (University of Toyama, Japan), Drug Discoveries & Therapeutics, 9(1): 13-22, 2015</h3><h3>57. "Oligonol Supplementation Modulates Plasma Volume and Osmolality and Sweating After Heat Load in Humans."</h3><h3>Jeong Beom Lee (Soonchunhyang University, Korea), Journal of Medicinal Food, 18(5): 578-583, 2015</h3><h3>2014</h3><h3>56. "Oligonol improves memory and cognition under an amyloid β25-35-induced Alzheimer's mouse model"等等……</h3><h3><br /></h3><h3><br /></h3><h3><br /></h3><h3><br /></h3><h3><br /></h3><h3><br /></h3><h3><br /></h3><h3><br /></h3>