<p class="ql-block"><b style="color:rgb(25, 25, 25); font-size:22px;">刚刚满月的宝宝，单次喂T50生命液就能达到1.5支。</b><b style="color:rgb(255, 138, 0); font-size:22px;">太岁液堪称专为全生命周期设计的温和营养精华，孕妇、婴儿乃至年长者都适合饮用，提供全面均衡的营养补充。</b></p><p class="ql-block"><b style="color:rgb(255, 138, 0); font-size:22px;">😻😻孕妇，婴儿，百岁老人皆可喝！</b></p><p class="ql-block"><b style="color:rgb(255, 138, 0); font-size:22px;">#食品</b></p> <p class="ql-block"><b style="color:rgb(25, 25, 25);">Pyrroloquinoline Quinone (PQQ) is a naturally occurring compound that functions as a redox cofactor, exhibiting significant biological activities. It has been recognized for its crucial roles in cellular energy production, antioxidant protection, and neurological health. Some propose it as a potential "14th vitamin," underscoring its importance. Below is a comprehensive analysis of PQQ's composition, health benefits, and commercial applications:</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);">1. Understanding PQQ: Composition and Sources</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Chemical Composition: PQQ, a small quinone molecule with the chemical formula C₁₄H₆N₂O₈, acts as a coenzyme in redox reactions. Its disodium salt form, PQQ-2Na, is often found in supplements.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Natural Occurrence: </b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - PQQ is present in trace quantities in various foods such as natto (61 ng/g), breast milk (140–180 ng/mL), spinach, green peppers, kiwifruit, and fermented foods.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - The body cannot synthesize PQQ; it must be ingested through diet or supplements.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);">2. Mechanisms of Action</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Mitochondrial Biogenesis: PQQ stimulates the creation of new mitochondria, potentially increasing their numbers by 163% as seen in human trials, thereby boosting ATP production.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Antioxidant and Anti-inflammatory Properties: </b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - It is highly efficient at scavenging free radicals, with a catalytic activity 5,000 times greater than vitamin C.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Activates the Nrf2 pathway, leading to upregulation of antioxidant enzymes like SOD and CAT, and reduces inflammation by downregulating IL-6 and TNF-α.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);">3. Health Impacts: Evidence-Based Benefits</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Brain and Cognitive Health: </b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Offers neuroprotection by inhibiting β-amyloid and α-synuclein, which are linked to neurodegenerative diseases like Alzheimer's and Parkinson's.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Enhances cognitive function, as a 12-week study with 20 mg/day showed improvements in memory, attention, and blood circulation in the brain of elderly participants.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - It has been shown to lower cortisol levels, reduce anxiety, and improve sleep quality.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Bone and Anti-Aging Benefits: </b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Prevents osteoporosis by stimulating bone formation and reducing oxidative stress in osteoblasts.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Promotes skin health by enhancing collagen production and protecting against UV-induced damage.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Metabolic and Cardiovascular Health: </b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Reduces visceral fat, enhances mitochondrial β-oxidation, and positively impacts gut microbiota.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Provides cardioprotection by reducing risks of heart hypertrophy, myocardial infarction, and side effects from statin use.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Improves insulin sensitivity, aiding in diabetes management, and mitigates complications like non-alcoholic fatty liver disease.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Longevity and Immunity: </b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Activates longevity-related genes SIRT1 and SIRT3, potentially extending lifespan.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Boosts immune function by enhancing the activity of B-cells, T-cells, and antibody production.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);">4. PQQ in Commercial Products: Formulations and Combinations</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Dosage: Typically, supplements offer dosage between 10–20 mg/day.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Popular Formulations: </b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - PQQ combined with CoQ10, enhancing mitochondrial energy, found in products by Jarrow Formulas and Doctor's Best.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Combined with phosphatidylserine (PS) to support cognitive function, seen in ESTHELIV Neuro Science.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Integration with DHA to maintain brain health, as in Swisse PLUS Brain Booster.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Included in beauty formulations with collagen for anti-aging benefits, such as in Allnature PQQ Complex.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Delivery Formats: Available in capsules, drinks, and functional foods like Wahaha PQQ effervescent tablets.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);">5. Safety and Considerations</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Toxicity: Long-term studies indicate no adverse effects like liver or kidney damage, even when used for up to 12 months in mice.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Precautions: The safety profile during pregnancy and lactation is not established; medical consultation is advised.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);"> - Regulatory Status: Recognized as a "new food ingredient" in China since 2022.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);">Conclusion</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);">PQQ is a versatile nutrient with significant benefits for brain, bone, metabolic, and skin health. Its role in enhancing mitochondrial function and mitigating oxidative stress makes it particularly valuable for aging populations. While typical dietary sources offer inadequate levels for therapeutic effects, supplementation, especially when paired with CoQ10 or DHA, provides a practical approach to harnessing its full potential. Continued research is likely to broaden its applications in preventing chronic diseases.</b></p><p class="ql-block"><b style="color:rgb(25, 25, 25);">For further reading, consider exploring studies on neuroprotection, osteoporosis mechanisms in *Aging Cell*, and detailed product formulations.</b></p>