<h3>国际输血协会(international society of blood transfusion,ISBT)对红细胞血型的定义是指使用人类同种抗体检测的红细胞表面抗原，它们是由基因所决定的一种遗传性状。到2020年10月为止，被ISBT正式认可的血型系统有38个（编号001～038），包含328个血型抗原；编号039、040和041血型系统尚处于待认可阶段。每个血型系统所包含的抗原和等位基因的更新资料，可在ISBT网站上查阅。</h3></br><h3>（一）血型抗原的分类</h3></br><h3>血型抗原被分为4大类：</h3></br><h3>①血型系统(system)。由1个或多个抗原组成，这些抗原受控于1个单独遗传位点，或者受控于2个或2个紧密连锁的同源位点，它们之间很少或根本没有观察到基因重组。</h3></br><h3>②血型集合（collection，又被称为200系列）。由若干个在血清学、生物化学或遗传学上有关的血型抗原组成，尚未达到可以定义为血型系统的标准。</h3></br><h3>③700系列(700 series)低频率血型抗原。它们的抗原频率小于1%，不被血型系统或血型集合所包含；</h3></br><h3>④901系列(901 series)高频率血型抗原。它们的抗原频率大于90%，不被血型系统或血型集合所包含。</h3></br><h3>（二）血型抗原的数字命名</h3></br><h3>最初血型抗原一般由发现者自行命名，被称为传统命名。而后，在1982年ISBT制定了统一的数字命名法，其基本原则是赋予每个血型系统和抗原独一无二的数字编号；一旦某数字给予特定对象，该数字随后不能再用于其他任何对象，即便该数字被注销。数字命名规则如下：</h3></br><h3>1.抗原</h3></br><h3>属于血型系统的抗原以6位数字表示，前3位数字为血型系统的编号，后3位数字为抗原特异性编号。比如MNS血型系统编号为002,S抗原特异性编号为003，因此S抗原的数字命名为002003。</h3></br><h3>2.表型</h3></br><h3>在系统符号后依次加冒号，并用逗号分隔抗原编号，表型中没有的抗原前面加减号表示。比如MNS血型表型M+N-S-s+记为MNS:1,-2,-3,4。</h3></br><h3>3.等位基因</h3></br><h3>系统符号后依次加星号和抗原编号，全部用斜体表示。比如MNS血型系统的M基因记为MNS*01。</h3></br><h3>4.基因型</h3></br><h3>系统符号后依次加星号和等位基因，单体型之间由斜线分隔，全部用斜体表示。比如MNS血型的基因型M/N记为MNS*01/MNS*02。</h3></br><h3>数字命名主要用于数字化存储血型抗原信息，并为基因分类提供框架，不适合日常交流使用。在出版物和日常工作等大多数情况下，一般使用最初发布的名称或符号，即传统命名。</h3></br><h3>表 血型抗原、表型、基因型命名示例</h3></br><h3> <br></br></h3></br><h3>（三）血型系统</h3></br><h3>截至2020年10月，被ISBT正式认可的血型系统及其包含的抗原列在表10-3。成为新血型系统的抗原，必须满足以下条件：</h3></br><h3>①抗原必须使用人同种抗体所鉴定；</h3></br><h3>②抗原必须是一个遗传性状；</h3></br><h3>③编码该抗原的基因必须被识别并有核酸序列资料；</h3></br><h3>④相应遗传位点已经在染色体上定位；</h3></br><h3>⑤该基因必须是不同于所有已知的血型基因，也不是与之紧密连锁的同源基因。</h3></br><h3>表 红细胞血型系统及抗原一览表</h3></br><h3> <br></br></h3></br><h3>续表</h3></br><h3> <br></br></h3></br><h3>续表</h3></br><h3> <br></br></h3></br><h3>注：ABO血型系统中的符号A,B是一个单独抗原；编号039、040、041血型系统目前处于待ISBT正式认可阶段。</h3></br><h3>（四）血型集合</h3></br><h3>这个类别中的抗原不属于血型系统，是一个临时分类。因为它们的遗传学分子基础尚未被阐明，一旦遗传位点在染色体定位后即可升级到血型系统。建立一个血型集合，必须包含2个或2个以上的抗原，而且这些抗原在血清学、生物化学或遗传等方面相互关联。血型集合以数字200开始编号，又被称为200系列。目前包含的抗原如表所示。</h3></br><h3>表 血型集合包含的抗原</h3></br><h3> <br></br></h3></br><h3>（五）700系列抗原</h3></br><h3>700系列抗原属于低频率抗原，在大多数群体中的抗原频率小于1%。列入该系列的抗原必须满足以下条件：</h3></br><h3>①不同于已知的血型系统抗原、血型集合抗原以及700系列抗原；</h3></br><h3>②被证明是1个遗传至少2代的遗传性状。低频率抗原通常是被一些抗体的意外反应所识别，这些抗体可能来自新生儿溶血病患儿母亲、导致交叉配型不合的额外抗体或是被包含在多重抗体血清中。</h3></br><h3>（六）901系列抗原</h3></br><h3>在大多数群体中901系列抗原的抗原频率大于90%。列入该系列的抗原要求满足以下条件：</h3></br><h3>①不同于所有其他已知的高频率血型抗原；</h3></br><h3>②在1个家庭中，至少有2个同胞被证明缺少该抗原，即证明该抗原阴性表型是一种遗传性状。表10-6为截至2020年10月，保留在901系列中的高频率抗原。应注意其中901012抗原Sda在ISBT较新版本中被升级为第038血型系统；901014抗原PEL于2020年被升级为第040号血型系统；901016抗原MAM于2020年被升级为第041号血型系统。</h3></br><h3>表 700系列抗原</h3></br><h3> <br></br></h3></br><h3>表 901系列抗原</h3></br><h3> 往期精彩文章回顾<a data-linktype="2" href="https://mp.weixin.qq.com/s?__biz=Mzg2MjcyNDE0Nw==&mid=2247483710&idx=1&sn=e5965f44164a46a89020d113f79d1eca&scene=21#wechat_redirect" localeditorid="6ogmpacxzg000000000" target="_blank" wah-hotarea="click">肾移植知识合集，很实用，建议关注、收藏、转发</a><br></br><a data-itemshowtype="0" data-linktype="2" hasload="1" 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